National Reyes Syndrome Foundation UK

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Inherited Metabolic Disorders Which Can Simulate Reye's Syndrome


Information providing a summary of each of the Metabolic Disorders which can simulate Reye's syndrome, and referred to in this section can be found by visiting Climb (Children Living with Inherited Metabolic Diseases) website:

To find the particular disorder go to the menu option titled "Inherited Metabolic Disorders" and look for the alphabetical listing under "A-Z Inherited Metabolic Disorders".  Climb provides up to date information in a non technical language, including brief summaries to pass on to family, schools and friends.  Technical information is also available to doctors and healthcare professionals.

The 26 identified Inherited Metabolic Disorders which can simulate Reye's syndrome (referred to in the "Introduction" to the "Reye-Like Syndromes" section) are listed under the following sub-heads viz:-

  • Lipid metabolism
  • Amino Acid Metabolism
  • Carbohydrates Metabolism
  • Other Defects

In the instances where the information about a condition is not provided by Climb, or there is a need for clarification, each note at the end of the appropriate listing draws the attention of the reader to the relevant detail.

These listings are updated by Dr. Simon Olpin, PhD, FRCPath, Lead Clinical Scientist in Metabolic Biochemistry, Sheffield Children's Hospital UK.

The NHS also provides information in respect of the following inherited metabolic disorders which simulate Reye's syndrome viz Isovaleric Acidaemia, Maple Syrup Urine Disease, and Medium-Chain Acyl CoA Dehydrogenase Deficiency.

For links to these three NHS websites see "Resources and Reports" relating
to "Lipid Metabolism" and "Amino Acid Metabolism"

Next review January 2020